Preliminary Research On Association Between Parvovirus B19 Infection And Kikuchi-Fujimoto Disease And It's Pathogenesis

Kikuchi-Fujimoto Disease (KFD), also called histiocytic necrotizing lymphadenitis, firstly reported by Kikuchi and Fujimoto and their colleagues separately in Japan in 1972, is a self-limited systemic disease which mainly affects lymph nodes. KFD is a world wide disease with a high prevalence among Asiatic females. The pathologic feature of the disease is a lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. The etiology and pathogenesis of the KFD are still unknown.Several reports linked the etiology of KFD to parvovirus B19 infection. But the diseases in their reports were necrotizing lymphadenitis accompanied to/by systemic lupus erythematosus or haemophagocytic syndrome, not purely KFD. When focusing on the association between parvovirus B19 and pure,idiopathic KFD (iKFD), only one paper with negative result was published.In this study, we firstly selected 33 paraffin embedded blocks of lymph node from patients with iKFD diagnosed after HE and CD68 immunohistochemistry (IHC) staining according to the diagnostic standard of KFD and excluding such diseases as Kimura's disease, rheumatoid arthritis, systemic lupus erythematosus and tuberculosis which can lead to necrotizing lymphadenitis. Blocks of lymph nodes from 16 patients with reactive lymph nodes were also selected as controls.