Basic Study On Effects And Mechanism Of Insulin-like Growth Factor Ⅰ On The Remolding Of Alveolar Bone In Diabetic Rats

Glucose is major energy for most mammalian cells, and it is necessary to maintain glucose in normal transport and metabolism. However, abnormally high level of glucose, as seen in diabetes, leads to the development of many chronic complications. The delayed wound healing of tooth extraction, the activation of alveolar bone absorption and the being hindered bone formation around the implants in diabetes are difficult to be solved for dentists. All of them have relationships with diabetic complications, such as osteopenia and infection. Insulin-like growth factor I IGF-I) shares sequence homology with human proinsulin and exhibits insulin-like effects. The therapeutic effects of IGF-I on the diabetic complications need more attention.Glucose Transporter-1(GLUT1) is the main transporter of glucose. High glucose could change the expression of GLUT1 in retinal endothelial cells, skin keratinocytes and mesangial cells, which may be involved in the pathogenesis of diabetic retinopathy, diabetic skin complications and diabetic nephropathy. GLUT1 appears to be expressed during development...