Study On Apoptosis Induced By TRAIL Combination With XIAP Antisense Oligodeoxy-nucleotide In Human Glioblastoma

Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is one of the several members of the tumour necrosis factor (TNF) gene su-perfamily that induce caspase-dependent apoptosis through engagement of death receptors (DRs). Caspase-3 is the key specific protease in apoptosis induced by TRAIL. Indeed, TRAIL induces apoptosis in a variety of cancer cell lines, includes cell lines derived from cancers of lung, colon, breast and thyroid, as well as from leukaemia and multiple myeloma. But the resistance of some cancer cells to TRAIL present the main obstacles for clinical experimentation. Therefore, new ways of sensitizing cancer cells to TRAIL-mediated apoptosis must be developed.X-linked inhibit apoptosis protein (XIAP) is a new member of inhibit apoptosis proteins ( IAPs) gene superfamily that inhibit cell apoptosis through engagement of caspases. Baculoviral inhibitor of apoptosis repeat...