Study On The Effect Of PI3K/Akt Pathway And Its Inhibitor LY294002 On The Pathogenesis And Treatment Of Lung Cancer

Lung cancer, one of the most common malignant tumors in today's world, is the major threat to the health and life of human because it leads the deaths caused by cancers in most countries. The current treatments of lung cancer include operation, chemotherapy and radiotherapy .Because of lack of specificity to cancer cells, all these methods have severe side effects while achieving their clinical response. Therefore, the mortality caused by lung cancer is still on the top of others though significant progresses have been made on these methods. In recent years, with the progression of medical molecular biology, targeted therapy aimed at the molecular events of lung cancer has been a focus of research. Drug targeting the specific molecules of tumor development opened a new way for the treatment of lung cancer. Studies in recent years have revealed that P13K/Akt signal transduction pathway is an important survival pathway in human, and regarded as the chief pathway for the survival of tumor cells. Akt is one of Ser (serine)/Thr (threonine) protein kinases, which occupies hinge location in these signal transductions. Akt2 is one member of Akt family. It plays an important role in tumorogenesis and development via multiple functions. Akt, a critical substrate of PI3K, is phosphorylated by PI3K activated by many growth factors and cytokines on the upstream. The increase of P-Akt (phospho-Akt) level contributes to activate the PI3K/Akt pathway. Activation of this pathway plays a pivotal role in enhancing tumor cell growth, proliferation, invasion and migration. Protein expression and activity of Akt...