Mouse Lewis Lung Carcinoma, C <sub> 57 </ Sub> Of Vegf Protein And Body Position Of The Role Of Experimental Studies Of Lung Plot Rather Square

Purpose: The aim of this study is to observe the influence of the prescription of Feijining to VEGF and body status in Lewis lung carcinoma (LLC) in C₅₇BL/6J mice.Material and method: C₅₇BL/6j mice are injected LLC subcutaneously. On the 5th day of successful modeling, 40 mice were randomized into model group (MG) , DDP group(DG), Feijining group (FG) and combination group(CG) after inoculating LLC cell. Weight and utonomic activities of mice were recorded . Spleen and thoracic gland were weighed which mice were sacrificed in each group respectively on the twelfth day. The pathomorphological observation of tumor tissues stained with HE by microscopy. VEGF protein expression of tumor tissues were detected by western blotting.Results:1. Weight, and frequency of utonomic activities of mice in FG were higher than the DG, with the same of CG than DG (p<0.05) .2. Index of spleen and thoracic gland of mice in FG and CG is higher than the DG(P<0. 05).3. Expression of VEGF protein of tumor tissues in CG was lower than DG(P<0. 05).4. Tumor inhibitory rate in CG is higher than in DG(P<0. 05).Conclusion: 1. The prescription of Feijining can prove body status of mice.2. The prescription of Feijining can enhance index of spleen and thoracic gland of mice.3. The prescription of Feijining can inhibit tumor growoth and has a cooperative effect with DDP.4. The prescription of Feijining can inhibit expression of VEGF protein of tumor tissues.