Serial Study Of Intracoronary Local Gene Transfer With Gelatin-coated Stent Preventing Restenosis After Stent Implantation In Mini-Swine Model

Part 1. In vitro quantitative study of absorption of pcDNA3.1/iNOS plasmid by improved gelatin-coated stent&Part 2. Feasibility study of tissue-membrane-covered stent as a new type of drug eluting platform in treatment of coronary restenosisPercutaneous transluminal coronary angioplasty (PTCA) and stent implantation, as one of effective methods for coronary revascularization, has been used world wide. But the main problem of restenosis has not been fully resolved. Recently,drug eluting stent has made distinct progress in treatment of coronary restenosis, but scholars still believe that there will be 10% of restenosis remained in the future clinical practice, so gene therary may play a certain role in finally resolving the problem.Gene therapy for preventing restenosis involves three aspects of studies: screening effective therapeutic gene, construction and improvement of vectors for mediating highly efficient transfection, and selection of mechanical local...