The Effect Of Fibrin Glue Perivenous Support On Structural Changes Of Rat Vein Grafts

Background:The patency rates of human vein grafts following coronary artery bypass grafting (CABG) are generally less favorable than those of selected arterial grafts. The mammary artery, the radial artery and the right gastro-epiploic artery are commonly used. Although vein grafts show less favorable patency rates, they still are used in most patients. Identification of factors promoting occlusion indicated that overdistention of the vein graft due to the higher arterial pressure, is an important factor in the damage of the vein graft wall. In animal and human in vitro experiments, and small clinical trials the beneficial effect of applying microporous, elastomeric, biodegradable perivenous support has been shown. However, easy to apply perivenous support is not available clinically. Every external application in the form of a graft or a stent implicates handling and instrumentation of the vein graft with subsequent risk of injury to the vein graft wall. Fibrin glue is elastic, biodegradablie, and permeable, and does not impede ingrowth of vasa vasorum. Fibrin glue may be an external graft support in the form of a spray, which can be applied immediatedly after completion of the bypass graft anastomoses and before exposure to high arterial pressure. Therefore we investigated the effect of fibrin glue perivenous support on structural changes of rat vein grafts.Part I The effect of fibrin glue perivenous support on the acute injury of rat vein grafts Objectives:To study the effect of fibrin glue perivenous on the acute injury of rat...