Clinical Studies On Level Of NT-proBNP In The Assessment, Treatment And Prognosis Of Chinese Patients With Chronic Left Heart Failure

Objectives:The aims of these serial studies were to evaluate the effects of NT-proBNP in Assessment, Treatment and Prognosis of patients with chronic left heart failure (CHF) in China, which included patients with different NYHA class, during acute onset, as well as before and after adrenergic receptor antagonist therapy. In addition, the reference level of NT-proBNP in the laboratory in healthy subjects was to determine.Methods:The patients (aged 18-80 years) with chronic left heart failure were included in this study, which were from the Dept. of inpatient, emergence room or outpatient in our hospital. All patients received conventional-therapy and were followed up till 2 years, of which some cases were observed dynamic changes of plasma NT-proBNP levels during acute onset in patients with chronic left heart failure; Another stable patients with chronic left heart failure were randomly assigned to either bisoprolol or carvedilol group for 7 months. Plasma concentrations of the N-terminal portion of brain natriuretic(NT-proBNP), rennin activity(PRA), angiotensin Ⅱ (AT Ⅱ) and aldosterone(Aldo) were detected by ELISA or RIA assay. At same time healthy subjects (aged 18 ~ 40 years) who were from pre-phase I clinical trial and blood donor, whose physical and Lab examination were normal, were included for setting Lab. Reference Value of NT-proBNP.Results:The serial studies included 5 sub-studies as following:(1) From Mar. 2003 to Apr 2004, 135 patients (97 male and 38 female, aged 60.7±13.1 years) with chronic left heart failure were included in this study. Most of patients included in...