Intimal Hyperplasia And The Effects Of Low Molecular Weight Heparin On Neointima Formation Associated With Experimental Pulmonary Embolism In Rats

[Backgroud]Pulmonary thromboembolism (PTE) is a major health concern with a high misdiagnostic rate. Given the recurrent nature and its being delayed of treatment, acute PTE may result in partial hemodynamic and anatomic resolution with a normal symptomatic status in most, and progression to pulmonary hypertension in a minority of patients. The process is accompanied with pulmonary vascular remodeling characterized by medial wall thickness of muscular arteries and muscularization of peripheral arteries, which may result from increased migration to intima and proliferation of smooth muscle cells (SMC). Both unfractionated heparin (UH) and low molecular weight heparin (LMWH) have been shown to inhibit the proliferation of SMC. We hypothesize that LMWH might suppress intimal hyperplasia of pulmonary vasculature associated with acute PTE.[Objective]1. To investigate the intimal hyperplasia of pulmonary artery after acute PTE.2. To study changes of monocyte chemoattractant protein-1 and platelet derived growth factor in lung tissue, and explore their roles in neointima formation associated with acute PTE.3. To investigate the effect of LMWH on intimal hyperplasia after acute PTE.[Methods]1. 90 male Sprague-Dawley rats were randomly divided into sham group (n=30),...