An Investigation Of The Relationship Between Chemo-resistance And Multidrug Resistance Gene 1 In Pancreatic Cancers

Within recent years, incidence of pancreatic cancer gradually increases. Pancreatic cancer mortality ranked fourth among malignant tumors in western countries. Pancreatic cancer is an aggressive disease with latent manifestation, non-specific symptoms, low operation resection rate, and low survival rate, whose patients have limited palliative treatment choices such as chemotherapy or radiotherapy. Even for post-operation patients, auxiliary chemotherapy and radiotherapy are imperative to eliminate residual tumor cells and prevent relapse. The role of chemotherapy has become more important due to its effect towards tumor lesion and metastasis, as well as remission of symptoms. However, besides presiding side effects such as bone marrow inhibition, chemo-resistance is currently a major obstacle in tumor chemotherapy. Therefore we encourage research on the expression of a multidrug resistance gene 1 and its relationship with chemo-resistance in pancreatic cancer, where prognosis is concerned.mdrl is one of the most important multidrug resistance genes .Through molecular and biological methods, we examined the expression of mdrl in pancreatic cancer, evaluating its relativity with chemo-resistance in pancreatic cancer, studying the mechanism of chemotherapy induced chemo-resistance in pancreatic cancer after establishing a SW1990/ADM cell line with MDR phenotype, with results posing as a helpful guide for pancreatic cancer clinical chemotherapy.We detected the expressions of mdrl at mRNA and protein levels in three...