Development Of Ganning Granula And The Study Of Its Fingerprints Of The Composition-effectiveness

The Ganning granula is made from Rhubarb and Ligusticum chuanxiong, which come from hospital preparation.This article is based on clinical practice, guided by traditional Chinese theory,preparation' s multi-composition, multi-avenue, multi-link, multi-target spot action, comprehensively applies modern science's new ideas, new theories, new techniques, new methods, multi-subject cross cooperation with each other ,pierces through the masterstroke of the traditional Chinese preparation' s therapeutical basis , systematically and comprehensively studies the ganning granula's explanation of prescription, optimization of preparation craft , making of quality standard ,experiment of pharmacodynamics and toxicology and the establishment of fingerprints.Explanation of prescription compatibility Demonstrate the theory of prescription compatibility, relocate its function and indication. Define the prescription that is Rhubarb (the principal drug). Ligusticum chuanxiong (the ministerial drug), which is used to treat the syndrome of hepatocholic hygropyrexia.Preparation craft Define the new preparation . Establish and optimize the craft and condition of extraction, separation, condensation and drying up. Establish the quality control standard of the intermediate. Obtain three satisfying sets data of samples. Discover the cis-trans isomerism tautormerism of Ligusticum chuanxiong ' s ferulic acid in the preparation process. At last, establish the composition -effectiveness of ganning granula and the new craft of the preparation.Formulation of the quality standard Formulate the ganning granula's quality standard draft plan. Establish the HPLC to mensurate ganning granula's composition-effectiveness, five conjugated anthraquinones(aloe-emodin, emodin, rhein, chrysophand, physcion) and ferulic acid. Add the content mensuration method of the Ligusticum chuanxiong 's ferulic acid which the 2005 edition pharmacopoeia...