Experimental Study On Prolonging The Survival Of Renal Allografts With AdEasy-1-CTLA4Ig And Regulatory T Cells In Rats

Organ transplantation is the unique effective way for the end organ function fail and cancer. The rejection of MHC-mismatched grafts is a major obstruction for the transplantation of tissues. The predominant approach to override this immunological barrier is the application of immunosuppressive drugs, such as CsA, Ramp, MMF and so on. However, the usage of such drugs that have to be given lifelong is accompanied by an increased incidence of serious infections and the development of tumors. In addition, these drugs have severe side effects and often inhibit the development of tolerance. Even in the presence of immunosuppressive drugs, many grafts are rejected after several years by mechanisms that are poorly understood. Therefore, the development of antigen-specific tolerogenic therapies ultimately leading to the acceptance of a graft is the objective of an increasing number of studies. Tolerance is the goal that everyone want to achieve. And Promising results have been obtained in some animal transplantation model . Thus , the novel strategy offers exciting perspectives for the development of safe and effective immunotherapy in clinical organ transplantation.The immune system, a highly effective and dynamic cellular network, protects a host from pathogens. Therefore, the immune system must distinguish self from nonself structures, but also between harmful and innocuous foreign antigens to prevent unessential and self-destructive immune responses. To maintain tolerance against self as well as protective immunity against pathogens, a sophisticated and highly balanced immune mechanism has evolved for generation of antigen-specific effector cell responses as well as antigen-specific tolerance induction.T cells play a critical role in the adaptive immune response by recognizing and responding to foreign antigens. Under appropriate stimulatory...