Experimental Study Of Neuronal Damage In Hippocampus Of Kanic Acid Induced Epileptic Rats And Protective Effect Of Topiramate

Status epilepticus (SE) refers to a condition that seizures occur frequently in a short time, and the patient keeps unconscious during the intermissions. SE could cause long-lasting damage of neurons (especially the ones in the limbic system), which makes an increment of chronic encephalopathy after SE. As a new type of anti-epileptic drug, Topiramate exerts its anti-epilepsy effects by different mechanisms. Recently, some reports suggested that Topiramate could protect the neurons. In this experiment, we make SE models of rats by two ways : i.p. administration of kanic acid, 12mg/kg (Group A) and i.v. injection of kanic acid on the tails, 10mg/kg (Group B). Then we observe the neuronal ultrastructure changes in hippocampal CA3 areas of the rats and the expression of Bax, Fas, caspase-3 to explore the mechanism of neuronal damage after SE. Meanwhile, pretreatment of Topiramate was used to study the possible mechanism of its protective effect on neurons.