Experimental Research Of Stenosis Of Internal Mammary Artery Graft After Coronary Artery Bypass Grafting

Objective: To set up new Chinese experimental swinish model of CABG and to study the effects of competitive flow from differently stenotic coronary artery on the flow and the content of endothelin (ET) and nitric oxide (NO) and calcitonin gene-related peptide (CGRP) and atrial natriuretic polypeptide (ANP) in the blood of internal mammary artery (IMA) graft.Methods : Coronary artery bypass grafting (CABG) was conducted in 15 Chinese experimental minipigs using left internal mammary artery(LIMA) anastomosed to left anterior descending artery (LAD) off pump. The proximal LAD was mad differently senotic (0%,30%,50%,75%,90% and 100%) through a flow occluder. When the proximal end of LAD was mad differently stenotic, the mean flow of LAD proximal and distal to the anastomotic stoma and the mean flow and the mode of blood flow and the pulsatility index (PI) value of LIMA were respectively measured through the transit time flow measurement (TTFM) and took blood sample from LIMA graft. The content of ET and NO and CGRP and ANP in the sample of LIMA graft were respectively measured.Results : Chinese experimental minipigs model of CABG were...