In Vivo Magnetic Resonance Tracking Of Feridex Labeled Bone Marrow-derived Neural Stem Cells After Autologous Transplantation In Rhesus Monkey

There is an increasingly enthusiastic interest in stem cells, cells with particular characteristics, as potential therapeutic reagents for various degenerative diseases and damaged organs. Stem cells may be defined as cells capable of proliferation, self-maintenance, and production of differentiated, functional progeny that are characteristic of the organ which they were derived from.Many studies have demonstrated the migrational capacity of stem or progenitor cells in mammalian brains during normal and pathophysiological conditions.The therapeutical potential of stem cell grafting has recently been studied in various pathological conditions of the brain. The clinical application of stem cell therapy to treat brain damage is dependent on the potential of grafts to promote sustained recovery after transplantation. Stem cells are infused or transplantated into tissue for therapeutic purposes.It was shown that the bone marrow stroma cells (BMSCs) might differentiate into neural stem cells (NSCs) and develop into neural cells ultimately. Therefore, the BMSCs -derived neural stem cells (BMSCs-D-NSCs) can be considered as ideal seed cells in replacement therapy of the cerebral degenerative diseases due to the...