Experimental Study On The Effect Of Exogenous Human Insulin-like Growth Factor Ⅰ Gene On The Proliferation Of Chondrocytes In Vitro

Articular cartilage injury caused by trauma or disease is common clinicaly. But there are not blood vessels and nerves in the cartilage tissues, so self-plerosis of the injury is not easy. The plerosis of articular cartilage injury is an important task in the aspects of clinincal and basic research on orthopaedics. Many researches show that organism activity gene plays an important role in regulating the mechanism of injury and plerosis of articular cartilage. For example, insulinlike growth factor(IGF) may irritate the phenotype of cartilage cell differentiation. And epidermal growth factor (EGF) has the effects of promoting mitosis and stimulating anabolism. Under the adjustment and control of cell growth factors, the cleavage and proliferation of the chondrocytes may be promoted in vitro.Although the chondrocytes cultivated in vitro are affected By these factors to promote the cleavage and proliferation of the chondrocytes, the internal environment of chondrocytes in the body is the result of the interaction and coadjustment of various factors. The active constituents are apt to be diluted or...