1.Clinic Study On The Adefovir Dipivoxil Treat Patients With HBeAg(+) Hepatitis B Resistant To Lamivudine 2.Preliminary Study On The Effect Of Severe Hepatitis Plasma On Umbilical Cord Blood Mesenchymal Stem Cells In Vitro

ObjectiveTo evaluate the efficacy and safety of adefovir dipivoxil in patients with HBeAg(+) hepatitis B resistant to lamivudine.MethodsThis study was conducted in patients with HBeAg(+) hepatitis B resistant to lamivudine.Lamivudine resistance has been difined as HBV DNA was once dropped, then elvated to 2 log10 copy/ml during the treatment of lamivudine. Eligible patients stopped lamivudine therapy and ten milligrams of adefovir dipivoxil was administered daily for 48weeks. ALT level, virological response (HBV DNA<103 copy/ml or dropped to 2 log10 copy/ml), and hepatitis B serology markers were assessed at regular intervals, the adverse events were also recorded.Results84 patients were received adefovir dipivoxil. After 12 weeks of treatment, normalization of ALT levels was 25%, normalization of ALT...