The Study On The Role Of Fibrinogen In The Mechanisms Underlying The Association Between Periodontal Disease And Coronary Heart Disease

A growing body of evidence from epidemiological studies implicats moderate and severe periodontitis with cardiovascular disease (CVD), especially coronary heart disease (CHD), and suggests that periodontitis may be one of the risk factors for CHD.But the mechanisms underlying the association between periodontitis and CVD are not clear.Fibrinogen, the clotting factor I, is an acute-phase protein, can be increased by approximately 2- to 10-fold during acute-phase response. A gene polymorphism of G/A variability in the -455 locus of the Bβ-fibrinogen promoter region has been shown to be associated with elevated plasma fibrinogen levels. It is now widely accepted that plasma fibrinogen levels are strongly associated with an increased risk of CVD and may be an independent risk factor of CHD. Periodontal inflammation can cause local production of pro-inflammatory cytokines that may exert an effect on the hepatic synthesis of fibrinogen and the elevation of fibrinogen plasma levels, which may in turn lead to increased inflammatory activity in atherosclerotic lesions and accelerated development of CHD. To date, nevertheless, can fibrinogen represent a possible candidate molecule that links periodontal disease with CHD is uncertainty. The relationship...