Proctected Effects Of Recombinant Human Growth Hormone On Rat Endotoxemia And Its Possible Mechanism

Sepsis is characterized as an abnormal systemic inflammatory response to an infection, which can be initiated by components located on or secreted by bacteria, viruses, and yeasts. Endotoxin is lipopolysaccharide (LPS) present in the outer portion of the cell wall of gram-negative bacteria. Exposure to endotoxin can result in fever, systemic inflammation, shock, and intravascular coagulation with severity of symptoms based on the amount of endotoxin present. Further, it can cause multiorgan dysfunction syndrome and death. In this condition, severe destructive metabolism may induce decrease of albumen production rate and negative nitrogen balance in body. Growth hormone is an important anabolic hormone, it has been showed that recombinant human growth hormone (rhGH) could enhance protein synthesis, promote tissue recovery, improve host defenses and decrease stress response, etc. Some results showed that rhGH had positive effects on critical illness. However, some studies showed that high doses of rhGH increased mortality of critical illness. So, the use of rhGH in sepsis therapy remains controversial. It is not yet clear whether low doses of rhGH have therapeutic effects on endotoxemia.