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Tissue Engineering Horizontal Rotating Bioreactor Development

Posted on:2007-04-20Degree:DoctorType:Dissertation
Country:ChinaCandidate:Y F ZhangFull Text:PDF
GTID:1104360185494640Subject:Biomedical engineering
Abstract/Summary:PDF Full Text Request
BackgroundAccording to a survey, there are as high as 400 billions US dollars to pay for the patients with whom damaged organs and tissues each year in United States, almost as much as half of American annual medical expenditure. There were about 8 millions organ transplant operations finished in the hospital for these American patients per year. Four thousand American people died when they are waiting for the transplant operation, and another 100 thousands people died even before they enter the waiting list. No exact associated statistical data are reported in China but the related material showed that the top number of the patients in the hospital in middle-scale city is the trauma and the intoxication, and the disease incidence is increasing by 7.5% annually. Meanwhile, the number of Chinese disabled is as high as 55 millions and 7.55 millions of them are the extremity disabled. Whatever what kinds of trauma or disabled they are, tissues repair and the function rebuild are needed to them.When the irreversible pathological changes occur to human body but can't be treated by any other therapies and the predicted death can't be avoided shortly, then the organs transplant will be done. There are many problems in the conventional transplants, donor organs lack seriously, even...
Keywords/Search Tags:Horizontal Rotating Bioreactor (HRB), Shear stress, Microgravity, canine Mesenchymal Stem Cells(cMSCs), EA.Hy926, endothelium cell
PDF Full Text Request
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