Studies On Biomimetic Methods To Fabricate Silk Fibroin/hydroxyapatite Scaffold For Bone Tissue Engineering

An ideal scaffold material is one of an important factors leading to the success in the field of bone tissue engineering. The scaffold materials provide mechanical stability and maintain a three-dimensional space for the formation of new bone tissue with appropriate structure. Silk fibroin (SF) is a natural fibrous protein and has been proved as a promising material for a number of biomedical and biotechnological applications because of its excellent biological compatibility, mechanical strength and biodegradation. Mimicking and fabricating the hierarchical organization would be one of the future ways to improve the biocompatibility of calcium phosphate/organics composites and to simulate the biological bone from its micro/meso-structure.The Ph.D thesis is focused on the study of the mineralization behavior of fibroin in order to fabricate three dimensional porous...