The Study On The Protective Effect And Mechanism Of Ischemic Postconditioning On Acute Renal Ischemic Reperfusion Injury

OBJECTIVEThe injury of transplant in early stage induced by immunological or nonimmunolofical factors may have an effect on the short and long-term survival of the transplant. Renal ischemic reperfusion injury is unavoidable in the transplantation process. As an important nonimmunological factor, renal ischemic reperfusion injury may cause acute inflammatory, significant organ damage or dysfunction, and remains an important problem for kidney transplantation. The warm ischemia time will be longer in the non-heart beating donors. And it has been shown that 30 minutes of warm ischemia is potentially more damaging than 24 hours of cold storage. In 2003, the study of Zhao demonstrated that ischemic postconditioning had protective effect on ischemic reperfusion injury of heart. In this study, we established a model of renal ischemic postconditioning in rat. And we have examined whether ischemic postconditioning has protective effect for renal warm ischemic reperfusion injury and explored its protective mechanism.