Experimental Study On Temporary Blocking Of Terminal Abdominal Aorta And Inferior Vein Cava And Isolated Perfusion Circulation

Objective: Animal experimental model was established in this study, to investigate the influences of temporary blocking of terminal abdominal aorta and inferior vein cava and isolated perfusion circulation (IPC) in SD rat on the heart rate, respiratory rate ,blood physiochemistry,ion in plasma,renal function,liver function and the recovery course of rat health;To explore the characteristic of pharmacokinetics of ADM after temporary blocking of terminal abdominal aorta and inferior vein cava and isolated perfusion circulation (IPC) with ADM in SD rat;To observe the condition apotosis and proliferation of bone marrow(BM) nuclear cell of medcine administered area and no medicine administered area after temporary blocking of terminal abdominal aorta and inferior vein cava and isolated perfusion circulation (IPC) with ADM in SD rat.part ?: Rat experimental model with temporary blocking of terminal abdominal aorta and inferior vein cava and isolated perfusion circulation (IPC)MethodsTwenty-four ( male and female) SD rats were used in this study, which were randomly assigned to group A,B,C,D(each group has six rats). The terminal abdominal aorta and inferior vein cava of group A,B,C,D were blocked and isolated perfusion circulation last respectively for 30 minutes,...