Safety And Efficacy Of Steroid Withdrawal In New Triple Immunosuppressant After Renal Transplantation: A Systematic Review

ObjectiveSteroids are widely adopted by clinical doctors post-transplantation, but it's difficult to control its side effects. So we want to evaluate the safety and efficacy of steroid withdrawal in new triple immunosuppression regimen after renal transplantation. The outcome measures we care about include: rate of acute and chronic rejection, rate of patient and graft survival, incidence of cardiovascular diseases, infection and tumor. Finally, we want to give some advice on whether and when steroids can be withdrawn in different conditions. Methods1. Search stratege1.1 Electronic search Medline (1990～2006.1), Embase (1990～2006.1)OVID (1990～2006.1), Cochrane Library (issue 4th, 2005), Chinese Biomedicine database (CBMdisc 1990～2006.1)1.2 Hand search: Chinese Journal of Organ Transplantation (1994～2005), other six Chinese Journals1.3 Search in the related web site2. Methodological quality of included studiesTwo reviewers scanned the articles independently. And we selected randomized...