Repair Mandibular Defects With BMP7 Gene Transduced MSCs On N-HA/PA66 Scaffold In Rabbit

One of the key challenges in oral and maxillofacial surgery is the treatment of bone loss because of tumor or trauma. Currently available materials for surgical replacement of the bone—such as autologous, allogenous, xenogenous grafts or artificialprosthesis—suffer from deficiencies such as donor site morbidity, limited tissue supply, immune rejection, potential transmission of pathogens.A tissue-engineered bone from the patient's own tissue-forming cells should overcome these deficiencies. Previous reports have demonstrated the ability to form mineralized bone in vitro and in vivo on porous biodegradable polymer scaffolds. For the treatment of large bone defects, the scaffold should be a three-dimensional scaffold, thus providing tissueforming cells with a mimicked environment of the extracellular matrix; enable blood vessel ingrowth by providing the right architecture and signals for angiogenesis. The cell source is an important factor for successful tissue regeneration. Mesenchymal stem cells (MSCs) are multipotent cells can differentiate into multiple cell types present in several tissues, including bone, fat, cartilage, and muscle, and can be obtained from the same individual easily. So the MSCs is a ideal candidates for a variety of cell-based therapies.The treatment of bone injure constitutes a major humanitarian and economic problem. An enormous expenditure will be cost during the long...