Methodologic Study And Clinical Significance Of Low Intensitive Anticoagulation Therapy Following Mechanical Heart Valve Replacement

Objective:To investigate the proper anticoagulation intensity and monitoring methods for anticoagulation therapy of patients following mechanical heart valve replacement in China. Methods: (1) The anticoagulation therapy intensity and the complications in 480patients of mechanical heart valve replacement were followed.. (2) To set up the International Normalized Ratio (INR) anticoagulationmonitoring methods.(3) Plasma concentration of prothrombin and warfarin, activity of coagulation factor Ⅶ (F Ⅶ) , INR, oral dosage of warfarin and anticoagulation complications were measured and analyzed in 65 patients following mechanical heart valve replacement.. Results:(1) The follow-up rate was 89.17%, and the total number was 2110.04 patient-years (Pty). The mean oral warfarin dosage was (2.38 ±...