Preventive And Therapeutic Effects Of Vasonatrin Peptide On Hypoxic Pulmonary Hypertension And Its Action Mechanism

Hypoxic pulmonary hypertension (HPH) is a harmful common disease to people's health and is a key link from chronic obstructive pulmonary disease (COPD) to cor pulmonale. The pathogenesis of HPH is still completely unknown, so at present lack of satisfactory and effective therapy to treat this disease. As the increase of incident and morbidity in cor pulmonale, preventive and therapeutic effect on HPH has been paid close attention. In recent years, it has been reported that atrial natriuretic peptide (ANP) has therapeutic values in HPH. Based on our previous findings of ANP and C-type natriuretic peptide (CNP) on cardiovascular action and study by Wei CM et al, a kind of new polypeptide termed vasonatrin peptide (VNP) is artificial synthesized and composed of 27 amino acids, which is a chimera of ANP and CNP. Preventive and therapeutic effects of VNP on HPH and its action mechanism are first investigated on system, organ and cell levels in vivo and in vitro in order to find a new theoretical ground and measure of therapy for HPH.In the present study, effects of VNP on development of HPH and estab-...