| The clinical use of the valved aortic homograft conduit (VAHC) has contributed greatly to the treatment of complicated congenital heart diseases and acquired aortic root diseases. Compared with other kinds of valved conduits used today, the VAHC received much attention for its excellent hemodynamic performance, durability, no need of anti-coagulation and greater anti-infection ability.With the development of cardiovascular surgery, many complicated congenital heart diseases, including some inoperable before, can be cured in the infant stage or even in the neonatal stage. Therefore, there is an increasing need for small valved conduits. Infants are in the developing stage, and it is unknown whether small VAHCs can grow in accordance with the development of the recipient normally or near normally and whether there are some changes of grafts in the recipient.So it is necessary to carry out further research. To our knowledge there has been no report on the study of the implantation of the neonatal animal's VAHC.This study was designed to observe whether the VAHCs of neonatal rabbits can grow in accordance with the develoment of young recipients normally and to study the changes of implants in the young and adult recipients by techniques of histology, immunology, immunohistologic chemistry and molecular biology. Neonatal New Zealand rabbits (birth time:3-5 days,weight:150-200g) were used as donors of VAHCs and young (0.9-1.2Kg) and adult(2.1-2.9Kg) rabbits as recipients. Twenty-four young and adult rabbbits were grouped according to the differences of the recipients and harvest time of specimens: group I and II -young recipient groups with specimens harvested 1 month and 6 months after the operation , group III and IV- two adult recipient groups with the same harvest time respectively. Each group had six animals. Unimplanted VAHCs of six neonatal rabbits were served as control group.The results are as follows:1. The modified model of the VAHC of the neonatal rabbit was...
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