An Experimental Study Of Biological Effects Of Platelet-Derived Growth Factor On Vascular Histiocytes

Platelet - derived growth factor (PDGF) is a polypeptide with multiple biological effects and a potent mitogen and chemical inducer in the body, widely distributed in platelets, endothelium, mononuclear phagocyte system, smooth muscle cells and the like. It's implicated in the growth and development of tissues, wound healing, and the formation and development of atherosclerosis (AS) and tumors. Modern medical studies have found that, besides abnormal cell proliferation and/or immunology, growth factors as PDGF and abnormal expression of oncogenes are involved as well in the pathogenesis of cardiovascular diseases (CVD) such as coronary heart disease (CHD) and hypertension. PDGF plays an important role not only in the regulation of the vascular structure and function, also in the process of CVDs, especially CHD and AS. The mechanism of action of PDGF on tissues and cells, its relations to other factors and its relations to oncogenes and AS are still unclear. The present study has been designed to investigate...