Imageologic And Pathologic Study Of The Anticancer Effect Of Bone Cement Pharmorubicin Mixture: An Experimental Evaluation

Percutaneous vertebroplasty is an interventional procedure intended to treat threatening collapse of vertebral body and agonizing pain in patients with weakened vertebral body. The common cause are severe osteoporosis, hemangiomas, and metastasis. Patients with spinal metastasis must receive radiation therapy after the procedure, since bone cement isn't an auticancer agent. In addition, radiation reaction might make patient's condition worse. We prepared the mixture of anticancer drug, pharmorubicin, with bone cement to treat the tumor model, in which the drug can kill tumor cell sustainedly to slow down the progression of lesion. There is no report about using this method in treatment of malignancies.Purposes:(1) To observe if pharmorubicin can be released from the cement.(2) To evaluate the activity of the released drug.(3) To detect the mechanism by which drug was released from the bone cement.(4) To establish rabbit VX₂ carcinoma model.(5) To observe the response of rabbit VX₂ cancer to pharmorubicin cement given by interventional method by menas of MR imaging and ³¹P MR spectroscopy.(6) To observe pathologic alterations of the VX₂ carcinoma model.Materials and Methods:(1) Elution test: the release peroid of pharmorubicin from bone cement was determined by colorimetry.