Experimental Study On ALI/ARDS And Severe Lung Contusion Induced By Thoracic Blunt Trauma In Cat

ALI/ARDS after trauma has been a prominent problem in clinic for many years. It is believed that incompletely understanding about its pathogenesis and inability to predict its incidence at early stage after trauma contribute to high mortality rates of ALI/ARDS. Recently accumulating evidences have suggested that complement activation is one of the most important early events in ALI/ARDS and the activated-fragments of complement may be the early indicator for ALI/ARDS. However, the relationship between complement activation and incidence of ALI/ARDS remains unclear and the prognostic value of activated-fragments of complement for ALI/ARDS is conflicted by different investigations. In order to probe into the mechanism of complement mediated-ALI/ARDS after thoracic blunt trauma and investigate the possibility that the changes of complement predict the incidence of ALI/ARDS, we developed serial studies as follow. Part I An ALI/ARDS model in cats induced by impact to thoracic wall45 cats were divided randomly into six groups according to the different combinations of different impact parameters. The thoracic blunt trauma was obtained by impact to right lateral chest wall in a relatively static pattern with XJ air powered impact system developed by our department. The rate of breath and heart beat as well as blood pressure were recorded continuously and blood gas analysis were performed at serial time points posttrauma. Morphologic and morphometric studies...