Changes In Expression Of Intracerebral Glutamate Transporter GLAST And Regulatory Mechanism Of NO In Audiogenic Seizure Rats

Aim: The etiology and pathogenesis of epilepsy, one of the chronic cerebral diseases, were not very clear. Though it was proved that glutamate plays a crucial role in epileptic events, the relationship between epilepsy and the reintake mechanism in the synaptic cleft mediated by glutamate transporter, is still at its primary stage. Furthermore, there is no domestic report concerned with it. There is no definite answer for whether NO, a special molecular messenger, functions as epilepsy inducer or antiepileptic factor. In addition, whether there exists an interregulatory factor between No and excitatory neurotransmitter glutamate also needs further study. This paper is to study the dynamic changes in the expression of intracerebral glutamate transporter GLAST in audiogenic seizure rats. Meanwhile the behavioral changes and changes in expression of GLAST in L-Arg andrg and L-NNA interfered audiogenic seizure rats were also observed.Methods: The experiment P⁷⁷PMC CEPRs rats were bought from the Experimental Animal Center of Beijing Medical University. The rats were randomly grouped as the control and the experimental, the latter were grouped as...