Study Of The Relationship Of Interleukin 2 And Estrogen Receptor In The Anterior Pituitary Of Rats

Interleukin 2(IL-2) is one of the cytokines shared by the network composed by nervous system, immune system and endocrinological system. It can influence the proliferation of pituitary cells and the production of pituitary hormones. Estrogen is a kind of steriod hormone which can affect the function of pituitary as well. Estrogen acts through the classical estrogen receptor (ER) which may mediate cellular proliferation through a number of intracellular signal pathways. ER includes two subtypes: ER α and ER β . Our previous study had found that there were some interactions between IL-2 and estrogen. The main purpose of my study is to further testify the relationship between IL-2 and estrogen receptor in the anterior pituitary and determine its molecular mechanism.To achieve this goal, I fully examine the morphological relationship between ER α /ER β immunoreactive products and IL-2 or its receptors first first;then observe the interaction of IL-2 and estrogen on the proliferation of the anterior pituitary...