| This article studied the changes of neuronal Ca2+ channel, content of noradrenaline (NA), 5-hydroxytryptamine ( 5-HT) 5-hydroxyindoleacetic acid (5-HIAA) and blood -brain barrier (BBB) permeability etc following brain injury to solve the mechanism of formation and development of brain edema. A total of 612 male wistar rats were used for the present experiment and divided into groups.Brain edema is one of the most important pathological changes in related to the prognosis of brain injury. The alteration of neuronal Ca2+ channel is concerning the neurobiochemical factor which aggravating brain edema, and it is a very interested topics in the neurosurgical field up to date. It has been. discovered Ca2+ served as a second intracellular messenger and it play a pivotal rote in delivering signals among neurons in the central nervous...
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