Experimental Research On The Effects Of Pulmonary Edema After Seawater Drowning On Traumatic Brain Edema In Rats

Objective: To investigate the effect of the pulmonary edema after seawater drowning on brain edema and the permeability of blood-brain barrier after brain injury in rats.Methods: Establish a animal model of moderate brain trauma with pulmonary edema after seawater drowning in rat: Adopt lateral fluid percussion model for traumatic brain injury, injecting seawater 4 ml/kg intratracheally after brain injury for pulmonary edema. (1)1 hour and 6 hours after brain injury, the water content and the ion content in the brain tissue were determined, and the edema formation and ultrastructural destruction in the brain tissue were assessed by light microscope(LM) and the electron microscope(EM) respectively.(2) EB and CG were used to evaluate the permeability of the blood brain barrier (BBB).Results: Comparing with the TBI group and the freshwater drowning group,the brain tissue water content, the Na⁺ and Ca²⁺ content and the EB content all increased...