Expression Of MTS1 In Human Bladder Cancer And Inhibitory Effects Of Wild-type MTS1 On Human Bladder Cancer Cell Line

Bladder cancer is one of the most common neoplasm in the world, its morbidity is the highest among all kinds of urinary system tumors and its recurrence rate is very high. A better understanding of molecular events directing the genesis and progression of bladder cancer would eventually provide specific diagnosis tools as well as targeting for therapeutic strategy. In recent years, most of the attention has gone to the MTS1 gene, discovered by Kamb and Noborl in 1994. MTS1 gene consisted of 3 exon and 2 intron located at 9p21 and coded a protein P16 which was identified as a major binding partner of Cyclin Dependent Kinase 4(CDK4) in cells. It was subsequently discovered that P16 gene resides within a locus commonly deleted in established cancer cell lines (75 % , higher than that of P53). Up to now,there was a little reports about the relationship between P16 expression and bladder cancer, and someone found that 33 % bladder cancer cell lines existing P16 deletions.In this report, We compared the expression of MTS1 gene in nomal bladder transitional cells with that of in bladder cancer cells in order to identify...