Missense Mutations And Gene-environment Interaction In Essential Hypertension And Myocardial Infarction Of Japanese Peoples

Objectives: Essential hypertension (EH) and coronary heart disease included myocardial infarction (MI) are kind of disease of multifactorial disorder determined by the interaction among environmental and genetic factors. Environmental factors have long been recognized as playing an important role in the pathogenesis of EH and MI, but individuals may vary in their response to these factors depending on differences in genes determining physiologic systems that mediate the response. Several causal genes determinants interact with environmental factors such as, for example, dietary salt to produce the final disease phenotype. Despite very significant recent progress in genomic and statistical tools, the genetic dissection of human essential hypertension still provides a major challenge. We performed association study between missense mutation of some causal genes related with lifestyle and EH and MI in Japanese population. The purpose of this study was to clarify the each contribution of genetic backgrounds and life styles to EH and MI via association study using some missense mutations with surely functional effect to phenotypes of multifactorial disorders.Methods: Association study was performed between missense mutation of some causal genes related with lifestyle and EH and MI in Japanese population. The candidate genes were selected based on their functions, including obesity (ADRB3), alcohol consumption (ALDH2),...