The Research Of Theory And Experiment On Tongshenluo Capsule Treating Diabetic Nephropathy

Objective: Utilizing collaterals disease theory to find the traditional Chinese medicine pathogenesis about the therapy of diabetic nephropathy.Based on collaterals disease theory, Tongshenluo capsule was developed .Through observing the effect on Tongshenluo capsule acting on diabetic nephropathy rat model renal function and the effect on Tongshenluo acting on cell hyperplasy ,cell cycle , cell factor ,secretion and cell cycle apoptosis in ectogenesis rat messangial cells of kidney cells in high -glucose condition, illuminate the protective effect on kidney of diabetic nephropathy and the correlative function mechanism,afford experimental proof for the therapy of diabetic nephropathy based on collaterals disease theory, prove the scientific value of Tongshenluo capsule and consequently improve the scientific value of collaterals disease theory.Method:Academic exploring: On the base of collecting the correlative articals of successive doctors and DN literature of the present age, according to collaterals disease theory to approached the pathogenesis of traditional Chinese medicine. It was found that"deficiency of both vital energy and yin"was invasion foundation,"collaterals and subcollaterals lock"and"Saliva to cohere expectoration to collect"were main pathocomponent,"collaterals rest product form"was the main pathoalter. The treatment of"supplementing qi and nourishing yin, removing blood stasis and dissipate phlegm, through collaterals removing qi stagnation"was established, On these grounds Tongshenluo capsule was formulated.Experimental research:1 The experiment about protective effect on Tongshenluo capsule acting on kidney of DN rat : Removal of half kidney...