| Delayed cerebral vasospasm (DCVS) is a major cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH). The exact mechanism underlying pathogenesis of vasospasm is not completely understood and no ideal scheme was found to prevent or treat DCVS though it has been studied for so many years. Recent evidences suggested that DCVS has something to do with the inflammation after SAH. Piperine its purity may reach 99 per cent is a kind of alkaloid extracted from fruits of pepper plants. It had been demonstrated for piperine to has the effects of sedation, anti-inflammation and anti-oxidative stress by modern pharmacology. Whereas effects of piperine on DCVS following SAH have not been reported. The aim of present study was to research whether piperine has a ability to attenuate DCVS at day 7 and its pharmacological mechanism by using of double-hemorrhage model of DCVS in rabbit. All of the study was divided into four parts.Part 1 Study for effect of piperine on pathological changes of delayed cerebral vasospasm following experimental subarachnoid hemorrhage in rabbitObjective The study was designed to determine if piperine can prevent or attenuate DCVS at day 7 following SAH in double-hemorrhage model by observing its effect on pathological changes of DCVS in rabbit. Methods 24 male New Zealand white rabbits, weighing between 1.8kg~2.2kg, were randomly divided into four groups(n=6), including shamed-operation group, Saline treated group, piperine-vehicle treated group (Piperine-vehicle is a kind of mixtured solution of sterilized distilled water, ethanol and Propylene glycol) and piperine treated group. Six animals in...
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