The Effects Of Variable Periods Of Ureteral Obstruction On Kidney And Relevant Research

Objective: Hydronephrosis is one of the most common urinary tract disease.The abnormalities of urinary system and the surrounding tissue can impair the flow of urine, lead to hydronephrosis and result in both alterations in renal structure and damage in renal function.Ureteral obstruction is the most frequently clinical cause of hydronephrosis.The exact time of onset ,duration and degree of ureteral obstruction in patients are usually unclearly, which restrict the systematic research on it.So far ,there are few data about human hydronephrotic natural course and renal function recovery after release of obstruction.The key question that urologists have concerned is that renal function reversibility after release of obstruction.Thus, the aim of this experimental study is to examine changes in renal shape,structure and function following variable periods of ureteral obstruction in rabbit models, to explore renal function reversibility after release of variable periods of ureteral obstruction, to evaluate the effect of benazepril on the obstructed renal function and its reversibility, and to investigate the effect of ureteropelvic junction obstruction on contralateral kidney.Methods: 1 Fifty-six adult New Zealand rabbits were used for the experiment and divided randomly into normal control group(n=8),sham operation group(n=8) and operation group(n=40). The latter was divided further into 5 pre-determined period groups(n=8).In sham operation group, left ureter was only exposed and not ligated;In operation group, left ureter was ligated completely. Toshiba Visart 1.5T MRI was performed 3 days, 1 week, 2 weeks, 4 weeks, 8 weeks respectively after ureteral obstruction to observe gross changes in renal structure. The obstructed renal weight was measured by electron balance. Intrapelvic pressure was measured by pelvic puncture under ultrasound examination. Urine was collected before obstruction and 3 days, 1...