Studies On Synthetic Polypeptide Vaccines

Several studies recently have indicated the potential of synthetic peptides as vaccine. The synthetic peptide vaccines will consist of a synthetic material comprising only the relevant antigenic moiety leading to protective immunity. Such vaccines can be synthesized in large amounts, and will not constitute any safety hazards to the individual or the community, Therefore, prospects for the development of such safe, cheap, stable and easily administered vaccines are good.Study on vaccine against schistosomiasis is looking for definite antigen, There have been no reports on the synthesis of immunogen yet. The surface antigen of schistosoma mansoni 28-KDa is studied to the potential of synthetic peptides as anti-schistosomiasis vaccine. The following twelve peptide fragments were chosen and synthesized:P26 Ala-Ala-Gly-Val-Asp-Tyr-Glu-Asp-Glu-Arg-Ile-Ser-Phe-Gln-Asp-Trp-Pro-LysP140 Cys-Glu-Ser-Leu-Lys-Gly-Ser-Thr-Gly-Lys-Leu-Ala-Val-Gly P115 Lys-Pro-Gln-Glu-Glu-Lys-Gla-Lys-Ile-Thr-Lys-Glu-Ile-Leu-Asn-Gly-Lys P24 Leu-Val-Ala-Ala-Gly-Val-Asp-Tyr-Glu-Asp-Glu-Arg-Ile-Ser-Phe-Gln-Asp-Trp-Pro-Lys P141 Glu-Ser-Leu-Lys-Gly-Ser-Thr-Gly-Lys-Leu-Ala-Val-Gly...