Influence On The Filament Dissolves System Of Experimental Rats Of Coronary Heart Disease With Principle Of Warmin Gyang Suplementing Heart And Activating Blood Circulation Resolving Phlegm

Objective: CHD is a common disease that threaten the human beings heaviously. It take the first place in the death rate of cardiovascular disease. In order to curative the principle of Warming Yang Suplementing Heart and Activating Blood circulation Resolving Phlegin to prevent and cure CHD. On base of the fore research, This topic deep into observation the influence of the principle of Warming Yang Suplementing Heart and Activating Blood circulation Resolving Phlegin to CHD on blood fat, hemorheological indeses, PAI-1, t-PA in the blood plasma.Methods: Adopt high fat diet and hypophysin to make the complex CHD rat model of Stagnation of Blood and phlegm by injecting high dose drug into the the visceral cavity. Utilize the biochemistry, immunohistochemistry, light microscope, electron microscope, PCR to detect blood fat, hemorheology, PAI-1, t-PA in the blood plasma and observe the PAI-1, t-PA Protein and gene expression in the cardiac muscle cell by the molecular biology method.Results: The experimental result shows that the principle of Warming Yang Suplementing Heart and Activating Blood circulation Resolving Phlegin has the functions of adjusting fat metabolism, improving the hemorheological indeses, protecting the heart ultrastructure , reducing PAI-1 in the blood plasma , increaseing t-PA, and suppressing the PAI-1 Protein and gene expression of cardic muscle cell and the aorta organizes , up-regulating the t-PA Protein expression of cardic muscle cell and the aorta organizes.Conclusion: The principle of Warming Yang SuplementingHeart and Activating Blood circulation Resolving Phlegin can effectively prevent and control myocardial ischemia, It is possibly through restraining PAI-1 gene expression , enhancing the activeness of filament dissolves system so as to low blood lipid, improve the hemorheological indeses to prevent and control CHD, which is better than other treatments.The principle of Warming Yang Suplementing Heart and Activating Blood circulation Resolving Phlegin has the functions of protecting the heart ultrastructure , improving the pathologicall state of myocardial ischemia, inhibiting the formation of atheromatous deposits. The principle of Warming Yang Suplementing Heart and Activating Blood circulation Resolving Phlegin is better than other treatments on two - way controller of PAI-1 and t-PA.