Prepareation And Experimental Study Of A Novel Biodegradable Mesh As Chest Wall Prosthesis

Objective: currently, the choice of chest wall prosthesis remains a challenging problem for thoracic and reconstructive surgeons. The purpose of this subject is to develop and to investigate the feasibility of new biodegradable chest wall prostheses. Methods: selecting and integrating perfectly the appropriate materials for the design and preparation of degradable chest wall prosthesis. The safety and efficiency was evaluated comprehensively by a series of biocompatibility test and an animal model of the chest wall defects and reconstruction. To explore the feasibility of using the porous biodegradable chest wall prosthesis as tissue-engineering scaffold, Canine Bone Mesenchymal Stem Cells (BMSC) were isolated, expanded in vitro, and then seeded on it. Results: the newly developed prosthesis, whose skeleton consists of Polydioxanone mesh, showed excellent biocompatibility and proper biodegradation rate. It is reabsorbed with 6 months and achieved perfect long-term chest wall stabilization. The cultured BMSC remained healthy and keep proliferation on the porous scaffold. Conclusions: Our experimental study shows that the newly developed biodegradable prostheses were favorable for chest wall reconstruction. And the porous composite mesh appears suitable for a scaffold for tissue-engineered chest wall.