The Study Of The Effect Of Different Drugs In Treament Of Acute Spinal Cord Injury

BACKGROUNDAcute spinal cord injury(SCI) is defined as an insult to the spinal cord that partially or completely interrupts the three main functions of the cord-motor, sensory, and reflex activities. It is mostly caused by motor vehicle accidents, falls, sports injuries and some other wounds. During years of unremitting efforts by scientists of many countries, with basic and clinical research of the spinal cord injury, treatment to the spinal cord injury has been developed much. However, it is not satisfactory. Considering the process of SCI, to decrase or to block the process may be an effective method. Though some drugs showed much effect in proctecting and improving the spinal function after injury, searching for an better means to improve its function is still an important subject to be solved.OBJECTIVETo study the effect of different drugs to the behavior and neurological changes , pathological and ultrastructural changes , the expression of neurofilament (NF) and glial fibrillary acidic protein (GFAP) ,and nerve cell apoptosis of spinal cord in rats after spinal cord injury. Then to find an effective method to cure SCI.METHODSTwo hundreds and sixteen healthy adult Sprague-Dawley rats were randomly divided into seven groups:blank control group, control group, experimental group. Build acute spinal cord injury model in rats with modified Allen's method after rats were anesthesed with drug administration through abdomin. Different drugs were given to cure spinal cord injury through tail vein each day. The follow index were observed at 8h,24h,96h,7day,14day:(1) to evaluate the function of spinal cord by...