Neuroprotective Effect Of High-Dose Methylprednisolone In Prophylaxis In Rat Acute Spinal Cord Injury

Objective To study the neuroprotective effect of different dose methylprednisolone in prophylaxis at different time and earlier complications in rat acute spinal cord injury. Methods Allen's weight drop model of acute spinal cord injury was prepared and to study the ratio of Tarlov's motor scales and Molt's inclined plane scales, motor evoked potentials, pathological and ultrastructural changes of spinal cord, neurofilament, glial fibrillary acidic protein and apoptosis of spinal cord after ASCI. Results The pathological changes of spinal cord were significantly improved in MP groups. And the motor evoked potentials were also significantly improved in MP groups. The neurological function of rats in MP groups was significantly improved at 72-hour after ASCI. The expression of NF significantly increased and GFAP significantly decreased in MP groups. The number of apoptosis in spinal cord significantly decreased in MP groups to SCI groups. Conclusion There is neuroprotective effect of high-dose methylprednisolone in prophylaxis in rat acute spinal cord injury. And it was the best that administration of 30mg/kg methylprednisolone 30min before SCI. The earlier complications of methylprednisolone were fewer.