| Background:There were mass calluses appeared at bone fractured ends of the patient who were suffered with injury of brain or SCI,even meanwhile ectopic ossification often appeared in muscle.The significant decease were showed in calluses strength ,speed of transformation from waven bone to lamellar bone.Therefore ,it is presumed that the nerve system not noly take part in fracture healing ,but also play important role in bone generation and bone transformation.With decalcifying immunohistochemistry method , it is the interesting note that the nonunited diaphyseal fracture,ectopic ossification bone have been observed to have an almost total lack of innervation , as denervated calluses .Then ,perhaps the above-mentioned three diseases would be treated eventually finally when the mechanism of nerve system what may dominate and regulate osteanagenesis is confirmed .Nerve growth factor was found in 1952 ,NGF as the first neurotrophic factor is a neutotrophic substance produced by most tissues of the body ,.Now it is known that NGF can regulate nerve center and promote the growth development differentiation of peripheral neurone and maintain normal survive of neurone. NGF may be found in all tissues of the body ,it not only nourish nerve ,but also take part in some physiological functions such as, the production and differentiation of monocyte and mastocyte ;healing of dermal ulcer,corneal ulcer,skin incision; growth of blood capillary ,at last, increase of topical blood supply.At present ,the research have testified the expression of NGF and NGF acceptor in normal bone tissue and calluses .the effect of NGF on fracture healing is obvious after topical and extrinsic source application of NGF.the result demonstrate that NGF is also a member of complicated factor net of fractured bone healing .it is new research...
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