Clinical And Laboratory Studies Of Airway Remodeling In Asthma

Part â… Quantitative analysis of CT lung density in patients with chronic asthma by high-resolution computed tomographyObjective: To determin the CT lung density in patients with chronic asthma by high-resolution computed tomographythe and explore the airway remodeling.Methods: Twelve patients with chronic stable asthma,10 stable chronic bronchitis and 7 healthy controls were included.All subjects underwent pulmonary function test,and the HRCT scans were performed at three selected levels:superior margin of the aortic arch,tracheal carina, and 2 cm above the right diaphragm within a 2 day period.The thickness of section cuts was 2 mm.During the scan,the patient held his/her breath at the end of full inspiratory. The 50mm2 region of interest (ROI) 5mm below pleura was chosen in the front, middle,and rear within all CT scan cuts respectively, and the value of the CT Lung density in these areas was measured.In five of the asthmatic patients CT scans and pulmonary function test were performed before and after treatment with Salbutamo.