Study On The Effect Of MMP-9 And TIMP-1 In Asthmatic Airway Remodeling And Regulatory Effect Of Antibody NGF With MMP-9

Asthma is a chronic disease of the airway which is clinically characterized by airway obstruction, enhanced bronchial responsiveness to spasmogens (airway hyperactivity), and it has not one more effect therapy. The reasch has confirmation that airway obstruction was the mostly reason for asthma. It can bring on asthmatic expression complex, enhanced therapeutic difficulty. The reason is durative airway damage and fabric abnormity. This is airway remodeling. The remodeling was reaction of repair after economy damage, but it differ for normal configuration and function. Matrix metalloproteinase (MMPs) was a batch proteinase contain zn²⁺ and ca²⁺ in their struct. It can participate some physiological functions and pathology course include embryonic development organi remodeling wounds repaired cell immigration tumour invasion and displace. MMPS and TIMP have deep relation with asthmti airway inflammation airway remodeling airway...