Study On Tumor Specific And Related Antigens Expressed In Human Esophageal Carcinoma

Human esophageal carcinoma is one of the most common cancers. It occurs at a high frequency in some area of China. The estimated rates of the cancer incidence are 16.4/100,000 for male and 10.2/100,000 for female in China. The rate of mortality of esophageal carcinoma in China is the highest among the cancer mortality in the five continents. The mortality rates of the cancer are 151/100,000 for male and 115/100,000 for female in China. Early diagnosis and early treatment are essential to reduction the rates of incidence and mortality. Endoscopic examinations were carried out in high-risk persons for early diagnosis. The intra-endoscopic local excision can be taken as an effective way of treating early esophageal carcinoma. However, it is difficult for us to carry out endoscopic examination in so many high-risk persons. Therefore, it is necessary to develop simple methods to help for the early diagnosis of esophageal carcinoma. It is also necessary to develop new therapy for esophageal carcinoma.Analysis of the expression of MAGE-1, MAGE-3 and NY-ESO-1 gene in human esophageal carcinoma and cloning of their cDNA from the carcinoma tissuesThe human genes of MAGE-1, MAGE-3, NY-ESO-1 encoded antigens that are recognized by autologous cytotoxic T lymphocytes. Tumor expressing MAGE-1, MAGE-3, NY-ESO-1 genes are potential targets for cancer...