| Diabetes mellitus is a common, frequently-occurring disease and its vascular complications is the main reason to cause disability and death in diabetic patients. By epidemiological survey, the risk of atherosclerosis and other cardiovascular complications in diabetic patients are 3~4 times of ordinary people and up to 70~80% of deaths in patients with diabetes are closely with vascular disease. Much less is know the mechanisms of triggering and the development in endothelial cells dysfuction and lesion underlying the diabetic condition. Advanced glycation end- products(AGEs) are a group of reversible and poisonous products formed by nonenzymatic glycation of glucose with protein and lipids under hyperglycemia condition. It not only directly results in the structure and function changes of the tissue in which AGEs deposited but also can interact with its receptor (receptor for AGEs, RAGE), a member of the immunologlobulin superfamily of cell surface molecules which express in range of cells including endothelial cell, smooth muscle cell and mononulear phagocytes, to result in dysfunction and lesion of the cells and play an important role in initiating vasculopathy. But it's still unknow the molecular mechanism of RAGE gene expression, regulation and also its signal transduction induced by AGEs in endothelium. In order to address this problem and provide theoretic basis of finding new measure for inhibition of AGEs-RAGE interaction, the underlying research works were carried out:1.The relationship between the AGEs and RAGE gene expression in endothelial cells(1) The relationships between of AGEs formation and RAGE expression in aortic and cardiac tissue of diabetic rats. The diabetic rat models were constructed with abdominal injection of...
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